She gained popularity through her acclaimed role Neelambari in Padayappa which also won her the Filmfare Award for Best Actress – Tamil. She also won the Filmfare Award for Best Supporting Actress – Telugu for the 2009 dramedy Konchem Ishtam Konchem Kashtam. Ramya's portrayal of Raj Mata Sivagami Devi in the Baahubali series (2015-17) received universal acclaim. While Baahubali: The Beginning (2015) is the fourth highest grossing Indian film, its sequel Baahubali 2: The Conclusion (2017) is the second highest grossing Indian film of all time. Her performance in Baahubali: The Beginning also won her the Best Supporting Actress – Telugu at the 2016 Filmfare Awards and Best Supporting Actress at Nandi Awards.
She married Telugu film director Krishna Vamsi on 12 June 2003. They have a son named Ritvick.
Ramya was born 15 September 1970 in a Tamil-speaking family to Krishnan and Maya.She is the niece of veteran Tamil comedian Cho Ramaswamy. She received initial training in Bharathanatyam, Western and Kuchipudi dance forms and has given many stage performances.